LABS: linear amplification-based bisulfite sequencing for ultrasensitive cancer detection from cell-free DNA

Abstract Methylation-based liquid biopsies show promises in detecting cancer using circulating cell-free DNA; however, current limitations impede clinical application. Most assays necessitate substantial DNA inputs, posing challenges. Additionally, underrepresented tumor DNA fragments may go undetec...

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Principais autores:	Xiao-Long Cui, Ji Nie, Houxiang Zhu, Krissana Kowitwanich, Alana V. Beadell, Diana C. West-Szymanski, Zhou Zhang, Urszula Dougherty, Akushika Kwesi, Zifeng Deng, Yan Li, Danqing Meng, Kevin Roggin, Teresa Barry, Ryan Owyang, Ben Fefferman, Chang Zeng, Lu Gao, Carolyn W. T. Zhao, Yuri Malina, Jiangbo Wei, Melanie Weigert, Wenjun Kang, Ajay Goel, Brian C.-H. Chiu, Marc Bissonnette, Wei Zhang, Mengjie Chen, Chuan He
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2024-06-01
Series:	Genome Biology
Assuntos:	Linear amplification Bisulfite sequencing Low-input DNA Cell-free DNA Cancer detection
Acceso en liña:	https://doi.org/10.1186/s13059-024-03262-2
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