A purpurin-based metalloimmunostimulant amplifies ROS and modulates STING/TNF-α axis to potentiate melanoma immunotherapy

The low infiltration of pro-inflammatory immune cells and the sustained activation of multiple immunosuppressive signaling pathways in melanoma significantly limit the efficacy of clinical immunotherapy. Therefore, developing an effective immunostimulant with reversing the immunosuppressive tumor mi...

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Detalles Bibliográficos

Principais autores:	Xiaoxin Yang, Mi Huang, Tianyi Pang, Dong Zhong, Hong Liu, Xiang Chen, Jun Liu, Yu Wen
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2026-04-01
Series:	Materials Today Bio
Assuntos:	Melanoma Metalloimmunostimulant ROS amplification TNF-α pathway Synergistic immunotherapy
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2590006426000463
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