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Single-cell tumor heterogeneity landscape of hepatocellular carcinoma: unraveling the pro-metastatic subtype and its interaction loop with fibroblasts

Abstract Background Tumor heterogeneity presents a formidable challenge in understanding the mechanisms driving tumor progression and metastasis. The heterogeneity of hepatocellular carcinoma (HCC) in cellular level is not clear. Methods Integration analysis of single-cell RNA sequencing data and sp...

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Principais autores: De-Zhen Guo, Xin Zhang, Sen-Quan Zhang, Shi-Yu Zhang, Xiang-Yu Zhang, Jia-Yan Yan, San-Yuan Dong, Kai Zhu, Xin-Rong Yang, Jia Fan, Jian Zhou, Ao Huang
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2024-08-01
coleção:Molecular Cancer
Assuntos:
Tumor heterogeneity
Single-cell
Hepatocellular carcinoma
Metastasis
Fibroblasts
Acesso em linha:https://doi.org/10.1186/s12943-024-02062-3
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