NsPEFs-enriched ADSCs-EVs alleviate osteoarthritis via RSPO3-mediated dual pro-chondrogenic and pro-M2 macrophage properties

Osteoarthritis (OA) remains a debilitating joint disorder due to the lack of disease-modifying therapies that can simultaneously halt cartilage degradation and modulate the aberrant immune microenvironment. This study demonstrated the therapeutic potential of extracellular vesicles derived from adip...

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Autors principals:	Yushan Wang, Yingjie Gao, Zhiyan Cao, Mingjie Dong, Pengfei Shao, Hao Fan, Zijian Guo, Xiaoyong Hu, Wenxiang Cheng, Pengcui Li, Wei Zhang, Yi Feng, Panfeng Fu, Zigang Ge, Jiake Xu, Chuan Xiang
Format:	Artigo
Idioma:	Inglês
Publicat:	KeAi Communications Co., Ltd. 2026-05-01
Col·lecció:	Bioactive Materials
Matèries:	Nanosecond pulsed electric fields (NsPEFs) Adipose-derived stem cells (ADSCs) Extracellular vesicles (EVs) Osteoarthritis R-spondin 3 (RSPO3)
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2452199X2600006X
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