Application of Plasmid Engineering to Enhance Yield and Quality of Plasmid for Vaccine and Gene Therapy

There is an increased interest in plasmid DNA as therapeutics. This is evident in the number of ongoing clinical trials involving the use of plasmid DNA. In order to be an effective therapeutic, high yield and high level of supercoiling are required. From the bioprocessing point of view, the superco...

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Autori principali:	Olusegun Folarin, Darren Nesbeth, John M. Ward, Eli Keshavarz-Moore
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2019-06-01
Serie:	Bioengineering
Soggetti:	<i>E. coli</i> plasmid bioprocessing plasmid supercoiling superhelical density plasmid engineering nanoparticle tracking analysis (NTA)
Accesso online:	https://www.mdpi.com/2306-5354/6/2/54
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