SMAD2 ubiquitination through PY motif regulates skeletal muscle mass and fibrotic degeneration

Abstract Transforming growth factorβ (TGFβ) signaling regulates diverse aspects of vertebrate skeletal muscle tissue including differentiation, homeostasis, regeneration and pathogenic degeneration. Ubiquitination of SMAD2, an intracellular transducer of TGFβ signaling, is a well-studied negative fe...

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Главные авторы:	Yuki Yamasaki, Keita Sakamoto, Shunki Yashiro, Yutaro Kawa, Akiko Kondow, Atsushi Kubo, Keisuke Hitachi, Masafumi Inui
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Nature Portfolio 2026-01-01
Серии:	Scientific Reports
Предметы:	Skeletal muscle TGF-beta Smad2 Ubiquitination Fibrosis
Online-ссылка:	https://doi.org/10.1038/s41598-026-37582-z
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