Forebrain knock-out of torsinA reduces striatal free-water and impairs whole-brain functional connectivity in a symptomatic mouse model of DYT1 dystonia

Multiple lines of evidence implicate striatal dysfunction in the pathogenesis of dystonia, including in DYT1, a common inherited form of the disease. The impact of striatal dysfunction on connected motor circuits and their interaction with other brain regions is poorly understood. Conditional knock-...

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Autores principales:	Jesse C. DeSimone, Samuel S. Pappas, Marcelo Febo, Roxana G. Burciu, Priyank Shukla, Luis M. Colon-Perez, William T. Dauer, David E. Vaillancourt
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2017-10-01
Colección:	Neurobiology of Disease
Materias:	Diffusion MRI DYT1 dystonia Free-water Functional connectivity Functional MRI Mouse model
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S0969996117301420
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