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Small molecule glucagon release inhibitors with activity in human islets

PurposeType 1 diabetes (T1D) accounts for an estimated 5% of all diabetes in the United States, afflicting over 1.25 million individuals. Maintaining long-term blood glucose control is the major goal for individuals with T1D. In T1D, insulin-secreting pancreatic islet β-cells are destroyed by the im...

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Autori principali: Michael A. Kalwat, Karina Rodrigues-dos-Santos, Derk D. Binns, Shuguang Wei, Anwu Zhou, Matthew R. Evans, Bruce A. Posner, Michael G. Roth, Melanie H. Cobb
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2023-04-01
Serie:Frontiers in Endocrinology
Soggetti:
glucagon
alpha cell
chemical biology
high-throughput (HT) screening
Type 1 diabetes (T1D)
Accesso online:https://www.frontiersin.org/articles/10.3389/fendo.2023.1114799/full
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