Metabolic characterization of tumor-immune interactions by multiplexed immunofluorescence reveals spatial mechanisms of immunotherapy response in non-small cell lung carcinoma (NSCLC)

Abstract Immune checkpoint inhibitors (ICI) have improved clinical outcomes for some patients with advanced NSCLC, however a substantial proportion of patients remain treatment resistant. Here we analyze the NSCLC tumor microenvironment (TME) using multiplexed immunofluorescence (mIF) of biopsies ta...

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Autores principales:	James Monkman, Aaron Kilgallon, Clara Lawler, Rafael Tubelleza, Thazin Nwe Aung, Jonathan H. Warrell, Ioannis Vathiotis, Ioannis P. Trontzas, Niki Gavrielatou, Nay Nwe Nyein Chan, Rotem Czertok, Shai Bookstein, Ken O’Byrne, Ettai Markovits, David L. Rimm, Arutha Kulasinghe
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2026-02-01
Colección:	Nature Communications
Acceso en línea:	https://doi.org/10.1038/s41467-026-68633-8
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