Vascular immunotargeting to endothelial determinant ICAM-1 enables optimal partnering of recombinant scFv-thrombomodulin fusion with endogenous cofactor.

The use of targeted therapeutics to replenish pathologically deficient proteins on the luminal endothelial membrane has the potential to revolutionize emergency and cardiovascular medicine. Untargeted recombinant proteins, like activated protein C (APC) and thrombomodulin (TM), have demonstrated ben...

Popoln opis

Bibliografske podrobnosti

Principais autores:	Colin F Greineder, Ann-Marie Chacko, Sergei Zaytsev, Blaine J Zern, Ronald Carnemolla, Elizabeth D Hood, Jingyan Han, Bi-Sen Ding, Charles T Esmon, Vladimir R Muzykantov
Format:	Artigo
Jezik:	Inglês
Izdano:	Public Library of Science (PLoS) 2013-01-01
Serija:	PLoS ONE
Online dostop:	http://europepmc.org/articles/PMC3828233?pdf=render
Oznake:	Označite Brez oznak, prvi označite!