Genetic and pharmacological targeting of A2a receptor improves function of anti-mesothelin CAR T cells

Abstract Background CAR T cell-based therapies have shown promising results in hematological malignancies. Results of CAR T cell projects in solid tumors have been less impressive, and factors including lack of targetable antigens and immunosuppressive tumor microenvironment (TME) have been suggeste...

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Detalhes bibliográficos

Principais autores:	Elham Masoumi, Leila Jafarzadeh, Hamid Reza Mirzaei, Khadijeh Alishah, Keyvan Fallah-Mehrjardi, Hosein Rostamian, Mohammad Khakpoor-Koosheh, Reza Meshkani, Farshid Noorbakhsh, Jamshid Hadjati
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2020-03-01
coleção:	Journal of Experimental & Clinical Cancer Research
Assuntos:	Mesothelin Chimeric antigen receptor Adenosine 2a-receptor Genetic targeting Pharmacological targeting Tumor microenvironment
Acesso em linha:	http://link.springer.com/article/10.1186/s13046-020-01546-6
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