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Time-synchronized immune-guided SBRT partial bulky tumor irradiation targeting hypoxic segment while sparing the peritumoral immune microenvironment

Abstract Background A novel unconventional SBRT-based PArtial Tumor irradiation targeting HYpoxic clonogenic cells (SBRT-PATHY) for induction of the tumoricidal bystander (BE) and abscopal effects (AE) was developed by translating our preclinical findings to a clinic in 2016. In order to further imp...

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Principais autores: Slavisa Tubin, Martin Ashdown, Branislav Jeremic
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2019-12-01
Serier:Radiation Oncology
Fag:
Immune-guided timing
Partial irradiation
Bystander effect
Abscopal effect
Tumor hypoxia
Immune microenvironment
Online adgang:https://doi.org/10.1186/s13014-019-1423-9
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