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Conformational Dynamics Related to Membrane Fusion Observed in Single Ebola GP Molecules

The Ebola virus (EBOV) envelope glycoprotein (GP) is a membrane fusion machine required for virus entry into cells. Following the endocytosis of EBOV, the GP1 domain is cleaved by cellular cathepsins in acidic endosomes, exposing a binding site for the Niemann-Pick C1 (NPC1) receptor. The NPC1 bindi...

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Principais autores: Dibyendu Kumar Das, Uriel Bulow, Natasha D. Durham, Ramesh Govindan, James B. Munro
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2020-06-01
Serier:Proceedings
Fag:
virus entry
membrane fusion
Ebola virus
single-molecule FRET
conformational dynamics
Online adgang:https://www.mdpi.com/2504-3900/50/1/49
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