Different associations between amyloid-βeta 42, amyloid-βeta 40, and amyloid-βeta 42/40 with soluble phosphorylated-tau and disease burden in Alzheimer’s disease: a cerebrospinal fluid and fluorodeoxyglucose-positron emission tomography study

Abstract Background Despite the high sensitivity of cerebrospinal fluid (CSF) amyloid beta (Aβ)42 to detect amyloid pathology, the Aβ42/Aβ40 ratio (amyR) better estimates amyloid load, with higher specificity for Alzheimer’s disease (AD). However, whether Aβ42 and amyR have different meanings and wh...

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Hlavní autoři:	Caterina Motta, Martina Gaia Di Donna, Chiara Giuseppina Bonomi, Martina Assogna, Agostino Chiaravalloti, Nicola Biagio Mercuri, Giacomo Koch, Alessandro Martorana
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2023-08-01
Edice:	Alzheimer’s Research & Therapy
Témata:	Alzheimer’s disease Cerebrospinal fluid biomarkers Amyloid beta 40 Amyloid beta 42 Amyloid beta 42/40 ratio Phosphorylated-tau
On-line přístup:	https://doi.org/10.1186/s13195-023-01291-w
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