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Nonsense-mediated mRNA decay: a key regulatory system engaged in cancer

Abstract Nonsense-mediated mRNA decay (NMD) is a critical cellular surveillance mechanism that prevents the translation of defective or deleterious proteins. The regulation of NMD, including both its activation and the evasion of its target mRNA, is intricately linked to tumorigenesis. When NMD beco...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Hongyu Pan, Xinyu Wu, Bingshuang Hu, Huihua Xiong, Yao Luo, Jian-Kang Zhou
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2025-11-01
Schriftenreihe:Cell Communication and Signaling
Schlagworte:
Nonsense-Mediated mRNA decay (NMD)
Cancer progression
Premature termination codon (PTC)
Alternative splicing
Tumor microenvironment
Therapeutic targeting
Online-Zugang:https://doi.org/10.1186/s12964-025-02503-6
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