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Detection of Histone H3 mutations in cerebrospinal fluid-derived tumor DNA from children with diffuse midline glioma

Abstract Diffuse midline gliomas (including diffuse intrinsic pontine glioma, DIPG) are highly morbid glial neoplasms of the thalamus or brainstem that typically arise in young children and are not surgically resectable. These tumors are characterized by a high rate of histone H3 mutation, resulting...

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Principais autores: Tina Y. Huang, Andrea Piunti, Rishi R. Lulla, Jin Qi, Craig M. Horbinski, Tadanori Tomita, C. David James, Ali Shilatifard, Amanda M. Saratsis
פורמט: Artigo
שפה:Inglês
יצא לאור: BMC 2017-04-01
סדרה:Acta Neuropathologica Communications
נושאים:
Cerebrospinal fluid
Liquid biopsy
Diffuse midline glioma
Diffuse intrinsic pontine glioma (DIPG)
H3K27M
גישה מקוונת:http://link.springer.com/article/10.1186/s40478-017-0436-6
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