Structural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8

Abstract The C-C motif chemokine receptor 8 (CCR8) is a class A G-protein coupled receptor that has emerged as a promising therapeutic target in cancer. Targeting CCR8 with an antibody has appeared to be an attractive therapeutic approach, but the molecular basis for chemokine-mediated activation an...

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Autors principals:	Dawei Sun, Yonglian Sun, Eric Janezic, Tricia Zhou, Matthew Johnson, Caleigh Azumaya, Sigrid Noreng, Cecilia Chiu, Akiko Seki, Teresita L. Arenzana, John M. Nicoludis, Yongchang Shi, Baomei Wang, Hoangdung Ho, Prajakta Joshi, Christine Tam, Jian Payandeh, Laëtitia Comps-Agrar, Jianyong Wang, Sascha Rutz, James T. Koerber, Matthieu Masureel
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2023-12-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-023-43601-8
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