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Beyond the interferon score: neurofilament light chain and glial fibrillary acidic protein capture immune-mediated neuroinjury and response to JAK inhibition in Aicardi–Goutières syndrome

Background and objectiveAicardi–Goutières syndrome (AGS) is a prototypical type I interferon–driven neuroimmunological disorder in which immune-mediated inflammation causes progressive brain injury. Targeted immunosuppression with Janus kinase (JAK) inhibitors has shown clinical benefit, yet neurolo...

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Principais autores: Lisa Wege, Christian Klemann, Sandy Siegert, Annette Bley, Sarah Koss, Anne Koy, Thorsten Langer, Franziska Dunst, Barbara Plecko, Martin Fleger, Fabian Speth, Tim Niehues, Peter Kaufmann, Jurek Schultz, Mohammed Attia, Johannes Stoffels, Beata Wolska-Kuśnierz, Roman Rolke, Gabriele Reichelt, Friederike Blankenburg, Jürgen Brunner, Katja Akgün, Christine Wolf, Min Ae Lee-Kirsch
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-04-01
Serier:Frontiers in Immunology
Fag:
Aicardi-Goutières syndrome
biomarker
immune-mediated neurodegeneration
inflammation
interferon
JAK inhibition
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1782352/full
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