CD28 engagement inhibits CD73-mediated regulatory activity of CD8+ T cells
Lai et al. report that the immunosuppressive molecule CD73 is negatively regulated by CD28 costimulation during CD8+ T cell activation. Their study implicates a lack of CD28 costimulation renders CD8+ T cells immunosuppressive and less able to eliminate solid tumors.
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| Principais autores: | , , , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Portfolio
2021-05-01
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| coleção: | Communications Biology |
| Acesso em linha: | https://doi.org/10.1038/s42003-021-02119-9 |
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