YAP-Dependent AXL Overexpression Mediates Resistance to EGFR Inhibitors in NSCLC
The Yes-associated protein (YAP) is a transcriptional co-activator upregulating genes that promote cell growth and inhibit apoptosis. The main dysregulation of the Hippo pathway in tumors is due to YAP overexpression, promoting epithelial to mesenchymal transition, cell transformation, and increased...
Gardado en:
| Principais autores: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Elsevier
2017-12-01
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| Series: | Neoplasia: An International Journal for Oncology Research |
| Acceso en liña: | http://www.sciencedirect.com/science/article/pii/S1476558617304001 |
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