Transcriptomic Responses to Polymyxin B and Analogues in Human Kidney Tubular Cells

Polymyxins are last-line antibiotics for the treatment of Gram-negative ‘superbugs’. However, nephrotoxicity can occur in up to 60% of patients administered intravenous polymyxins. The mechanisms underpinning nephrotoxicity remain unclear. To understand polymyxin-induced nephrotoxicity, human renal...

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Hlavní autoři:	Mengyao Li, Mohammad A. K. Azad, Philip E. Thompson, Kade D. Roberts, Tony Velkov, Yan Zhu, Jian Li
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2023-02-01
Edice:	Antibiotics
Témata:	polymyxin nephrotoxicity transcriptomics metallothioneins
On-line přístup:	https://www.mdpi.com/2079-6382/12/2/415
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