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HP1γ self-assembles and cooperates with KAP1 in repression of long noncoding RNA AI662270 in ESCs

Summary: HP1s are involved in the assembly of heterochromatin and transcriptional regulation. Here, we report the molecular mechanisms underlying binding of the chromoshadow domain of HP1γ (HP1γCSD) to the transcriptional co-repressor KAP1 and HP1γ self-assembly. Using crystallography, NMR, and mass...

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I tiakina i:
Ngā kaituhi matua: Nitika Gaurav, Weihua Qin, Karthik Selvam, Ziling Zhou, Jiuyang Liu, Yanshuang Yin, Rohit K. Singh, Ryan A. O’Hara, Zohreh Tavaf, Amarjeet Kumar, Hidetoshi Kono, Geeta J. Narlikar, Laura A. Banaszynski, Heinrich Leonhardt, Tatiana G. Kutateladze
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Elsevier 2026-02-01
Rangatū:Cell Reports
Ngā marau:
CP: molecular biology
CP: stem cell research
Urunga tuihono:http://www.sciencedirect.com/science/article/pii/S2211124725016468
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