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Aspirin modulates generation of procoagulant phospholipids in cardiovascular disease, by regulating LPCAT3

Enzymatically oxygenated phospholipids (eoxPL) from lipoxygenases (LOX) or cyclooxygenase (COX) are prothrombotic. Their generation in arterial disease, and their modulation by cardiovascular therapies is unknown. Furthermore, the Lands cycle acyl-transferases that catalyze their formation are unide...

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Hoofdauteurs: Majd B. Protty, Victoria J. Tyrrell, Ali A. Hajeyah, Bethan Morgan, Daniela Costa, Yong Li, Anirban Choudhury, Rito Mitra, David Bosanquet, Alex Reed, Iuliia K. Denisenko, Katsuyuki Nagata, Hideo Shindou, Benjamin F. Cravatt, Alastair W. Poole, Takao Shimizu, Zaheer Yousef, Peter W. Collins, Valerie B. O’Donnell
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2025-01-01
Reeks:Journal of Lipid Research
Onderwerpen:
lipidomics
thrombosis
phospholipids
acute coronary syndrome
platelets
Online toegang:http://www.sciencedirect.com/science/article/pii/S0022227524002323
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