Conformational change of Dishevelled plays a key regulatory role in the Wnt signaling pathways
The intracellular signaling molecule Dishevelled (Dvl) mediates canonical and non-canonical Wnt signaling via its PDZ domain. Different pathways diverge at this point by a mechanism that remains unclear. Here we show that the peptide-binding pocket of the Dvl PDZ domain can be occupied by Dvl's own...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
eLife Sciences Publications Ltd
2015-08-01
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| Серии: | eLife |
| Предметы: | |
| Online-ссылка: | https://elifesciences.org/articles/08142 |
| Метки: |
Нет меток, Требуется 1-ая метка записи!
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