Establishment of Stable Knockdown of MACC1 Oncogene in Patient-Derived Ovarian Cancer Organoids

High-grade serous ovarian cancer (HGSOC) remains the most lethal gynecological malignancy, and there is still an unmet medical need to deepen basic research on its origins and mechanisms of progression. Patient-derived organoids of high-grade serous ovarian cancer (HGSOC-PDO) are a powerful model to...

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Principais autores:	Sophia Hierlmayer, Liliia Hladchenko, Juliane Reichenbach, Christoph Klein, Sven Mahner, Fabian Trillsch, Mirjana Kessler, Anca Chelariu-Raicu
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2024-12-01
Series:	Methods and Protocols
Assuntos:	ovarian cancer patient-derived organoids lentiviral transduction MACC1 oncogenic mechanisms knockdown validation
Acceso en liña:	https://www.mdpi.com/2409-9279/7/6/104
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