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Inhibition of Leishmania Major PTR1 Gene Expression by Anti-sense in Escherichia Coli

Background:Protozoa related to Trypanosome family including Leishmania,synthesize enzymes to escape from drug therapy.One of them is PTR1 that its enzymatic activity is similar to dihydrofolate reductase(DHFR)Dihydrofolate reductase - thymidylate synthase has a major role in DNA synthesis, if it is...

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Main Authors: M Mohebali, F Mahboudi, A Haghighi, M Bandehpour, F Kheirandish, B Kazemi
Format: Artigo
Language:Inglês
Published: Tehran University of Medical Sciences 2012-05-01
Series:Iranian Journal of Public Health
Subjects:
PTR1
Leishmania Major
Antisense Plasmid
Dihydrofolate Reductase
Expression
Online Access:http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/20898.pdf&manuscript_id=20898
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