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Increased sphingomyelin content impairs HDL biogenesis and maturation in human Niemann-Pick disease type B

We previously reported that human Niemann-Pick Disease type B (NPD-B) is associated with low HDL. In this study, we investigated the pathophysiology of this HDL deficiency by examining both HDL samples from NPD-B patients and nascent high density lipoprotein (LpA-I) generated by incubation of lipid-...

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Principais autores: Ching Yin Lee, Alain Lesimple, Maxime Denis, Jérôme Vincent, Åsmund Larsen, Orval Mamer, Larbi Krimbou, Jacques Genest, Michel Marcil
פורמט: Artigo
שפה:Inglês
יצא לאור: Elsevier 2006-03-01
סדרה:Journal of Lipid Research
נושאים:
high density lipoprotein
nascent LpA-I
phospholipids
sphingomyelin phosphodiesterase-1 gene
sphingomyelinase
גישה מקוונת:http://www.sciencedirect.com/science/article/pii/S0022227520336166
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