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Glycosylation States on Intact Proteins Determined by NMR Spectroscopy

Protein glycosylation is important in many organisms for proper protein folding, signaling, cell adhesion, protein-protein interactions, and immune responses. Thus, effectively determining the extent of glycosylation in glycoprotein therapeutics is crucial. Up to now, characterizing protein glycosyl...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Audra A. Hargett, Aaron M. Marcella, Huifeng Yu, Chao Li, Jared Orwenyo, Marcos D. Battistel, Lai-Xi Wang, Darón I. Freedberg
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2021-07-01
Schriftenreihe:Molecules
Schlagworte:
glycosylated proteins
heteronuclear NMR
HSQC-TOCSY
natural abundance
T<sub>2</sub> filter
glycoprotein
Online-Zugang:https://www.mdpi.com/1420-3049/26/14/4308
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