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Elevated Cerebrospinal Fluid Anti-CD4 Autoantibody Levels in HIV Associate with Neuroinflammation

ABSTRACT The mechanisms of persistent central nervous system (CNS) inflammation in people with HIV (PWH) despite effective antiretroviral therapy (ART) are not fully understood. We have recently shown that plasma anti-CD4 IgGs contribute to poor CD4+ T cell recovery during suppressive ART via antibo...

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Main Authors: Da Cheng, Zhenwu Luo, Xiaoyu Fu, Sophie Stephenson, Clara Di Germanio, Philip J. Norris, Dietmar Fuchs, Lishomwa C. Ndhlovu, Quan-zhen Li, Henrik Zetterberg, Magnus Gisslen, Richard W. Price, Shifang Peng, Wei Jiang
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2022-02-01
Series:Microbiology Spectrum
Subjects:
HIV-1 infection
neuroinflammation
anti-CD4 IgG
cerebrospinal fluid
HIV
anti-CD4 autoantibody
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01975-21
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