Activation of the VPAC2 Receptor Impairs Axon Outgrowth and Decreases Dendritic Arborization in Mouse Cortical Neurons by a PKA-Dependent Mechanism

Clinical studies have shown that microduplications at 7q36.3, containing VIPR2, confer significant risk for schizophrenia and autism spectrum disorder (ASD). VIPR2 gene encodes the VPAC2 receptor for vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP)....

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Главные авторы:	Shuto Takeuchi, Takuya Kawanai, Ryosuke Yamauchi, Lu Chen, Tatsunori Miyaoka, Mei Yamada, Satoshi Asano, Atsuko Hayata-Takano, Takanobu Nakazawa, Koji Yano, Naotaka Horiguchi, Shinsaku Nakagawa, Kazuhiro Takuma, James A. Waschek, Hitoshi Hashimoto, Yukio Ago
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Frontiers Media S.A. 2020-06-01
Серии:	Frontiers in Neuroscience
Предметы:	VPAC2 receptor psychiatric disorders cortical neurons axon dendrite
Online-ссылка:	https://www.frontiersin.org/article/10.3389/fnins.2020.00521/full
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