Rhapontigenin attenuates neurodegeneration in a parkinson’s disease model by downregulating mtDNA-cGAS-STING-NF-κB-mediated neuroinflammation via PINK1/DRP1-dependent microglial mitophagy

Abstract Microglial activation-induced neuroinflammation and impaired neuronal mitophagy are recognized as pivotal pathogeneses in Parkinson’s disease (PD). However, the role of microglial mitophagy in microglial activation during PD development remains unclear, and therapeutic interventions targeti...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Zhongqiang Su, Hui Shu, Xingting Huang, Liuyan Ding, Fengchu Liang, Zongtang Xu, Ziting Zhu, Minshan Chen, Xiaobei Wang, Guihua Li, Huan Xia, Qiannan Cao, Wenlong Zhang, Pingyi Xu, Xinling Yang
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Springer 2025-09-01
Sarja:	Cellular and Molecular Life Sciences
Aiheet:	Rhapontigenin Neuroinflammation CGAS-STING Parkinson's disease Microglial mitophagy Mitochondrial DNA
Linkit:	https://doi.org/10.1007/s00018-025-05873-9
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