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Evidence for formation of hydroxyl radicals during reperfusion after global cerebral ischaemia in rats using salicylate trapping and microdialysis

Systemic administration of salicylate (SA) to rats (100 mg kg−1i.p.) was used as anin vivotrap of hydroxyl radicals (·OH). In the brain SA reacts with hydroxyl radicals to form the stable adducts 2,3- and 2,5 dihydroxybenzoic acid (DHBAs) which can thus be taken as an index of·OH formation. The DHBA...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Thomas Christensen, Torben Bruhn, Torben Balchen, Nils H. Diemer
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 1994-12-01
Schriftenreihe:Neurobiology of Disease
Schlagworte:
cerebral ischaemia
dihydroxybenzoic acid
hydroxyl radicals
microdialysis
rat
salicylate trapping
Online-Zugang:http://www.sciencedirect.com/science/article/pii/S0969996184700167
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