Model‐Informed Drug Development of Subcutaneous Nivolumab: Comparison of Pharmacokinetic Analysis Methodologies Using Clinical Trial Simulation
ABSTRACT A subcutaneous formulation of nivolumab was evaluated in the phase III study CheckMate 67T (NCT04810078). The co‐primary pharmacokinetic exposure endpoints, time‐averaged serum concentration over the first 28 days (Cavgd28), and steady‐state trough concentration (Cminss) were determined thr...
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| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Wiley
2025-12-01
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| coleção: | CPT: Pharmacometrics & Systems Pharmacology |
| Assuntos: | |
| Acesso em linha: | https://doi.org/10.1002/psp4.70120 |
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