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Kinetics and MR-Based Monitoring of AAV9 Vector Delivery into Cerebrospinal Fluid of Nonhuman Primates

Here we evaluated the utility of MRI to monitor intrathecal infusions in nonhuman primates. Adeno-associated virus (AAV) spiked with gadoteridol, a gadolinium-based MRI contrast agent, enabled real-time visualization of infusions delivered either via cerebromedullary cistern, lumbar, cerebromedullar...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Kousaku Ohno, Lluis Samaranch, Piotr Hadaczek, John R. Bringas, Philip C. Allen, Vivek Sudhakar, Diane E. Stockinger, Christopher Snieckus, Michael V. Campagna, Waldy San Sebastian, Jerusha Naidoo, Haifeng Chen, John Forsayeth, Ernesto A. Salegio, Granger G.C. Hwa, Krystof S. Bankiewicz
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2019-06-01
Schriftenreihe:Molecular Therapy: Methods & Clinical Development
Online-Zugang:http://www.sciencedirect.com/science/article/pii/S2329050118301232
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