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A Computational Model of Loss of Dopaminergic Cells in Parkinson's Disease Due to Glutamate-Induced Excitotoxicity

Parkinson's disease (PD) is a neurodegenerative disease associated with progressive and inexorable loss of dopaminergic cells in Substantia Nigra pars compacta (SNc). Although many mechanisms have been suggested, a decisive root cause of this cell loss is unknown. A couple of the proposed mechanisms...

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Principais autores: Vignayanandam Ravindernath Muddapu, Alekhya Mandali, V. Srinivasa Chakravarthy, Srikanth Ramaswamy
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019-02-01
Serier:Frontiers in Neural Circuits
Fag:
Parkinson's disease
excitotoxicity
deep brain stimulation
Izhikevich neuron model
Substantia Nigra pars compacta
SubThalamic Nucleus
Online adgang:https://www.frontiersin.org/article/10.3389/fncir.2019.00011/full
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