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Pirfenidone increases IL-10 and improves acute pancreatitis in multiple clinically relevant murine models

Despite decades of research, there is no specific therapy for acute pancreatitis (AP). In the current study, we have evaluated the efficacy of pirfenidone, an antiinflammatory and antifibrotic agent that is approved by the FDA for treatment of idiopathic pulmonary fibrosis (IPF), in ameliorating loc...

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Autors principals: Ejas Palathingal Bava, John George, Mohammad Tarique, Srikanth Iyer, Preeti Sahay, Beatriz Gomez Aguilar, Dujon B. Edwards, Bhuwan Giri, Vrishketan Sethi, Tejeshwar Jain, Prateek Sharma, Utpreksha Vaish, Harrys K. C. Jacob, Anthony Ferrantella, Craig L. Maynard, Ashok K. Saluja, Rajinder K. Dawra, Vikas Dudeja
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical investigation 2022-01-01
Col·lecció:JCI Insight
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Accés en línia:https://doi.org/10.1172/jci.insight.141108
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