Bradykinin measurement by liquid chromatography tandem mass spectrometry in subjects with hereditary angioedema enhanced by cold activation

Background: Bradykinin (BK), a 9–amino acid peptide, is a key mediator responsible for angioedema attacks in hereditary angioedema due to C1INH deficiency (HAE-C1INH). Current BK assays lack clinical utility due to the instability of BK (half-life < 30 seconds) and low pg/mL baseline levels. Objecti...

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Principais autores:	Jinguo Chen, MD, Yunkou Wu, PhD, J. Joanna Yu, MD, PhD, Joseph Chiao, MD, Jing Yu, PhD, Mark D. Scarupa, MD, Lili Wan, PhD, H. Henry Li, MD, PhD
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Elsevier 2025-08-01
סדרה:	Journal of Allergy and Clinical Immunology: Global
נושאים:	Hereditary angioedema angioedema bradykinin plasma kallikrein contact system cold activation
גישה מקוונת:	http://www.sciencedirect.com/science/article/pii/S2772829325001067
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