Unwinding the SARS-CoV-2 Ribosomal Frameshifting Pseudoknot with LNA and G-Clamp-Modified Phosphorothioate Oligonucleotides Inhibits Viral Replication

Ribosomal frameshifting (RFS) at the slippery site of SARS-CoV-2 RNA is essential for the biosynthesis of the viral replication machinery. It requires the formation of a pseudoknot (PK) structure near the slippery site and can be inhibited by PK-disrupting oligonucleotide-based antivirals. We obtain...

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Bibliografische Detailangaben

Hauptverfasser:	Ekaterina Knizhnik, Stepan Chumakov, Julia Svetlova, Iulia Pavlova, Yuri Khodarovich, Vladimir Brylev, Vjacheslav Severov, Rugiya Alieva, Liubov Kozlovskaya, Dmitry Andreev, Andrey Aralov, Anna Varizhuk
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2023-11-01
Schriftenreihe:	Biomolecules
Schlagworte:	SARS-CoV-2 ribosomal frameshifting oligonucleotides modification antivirals locked nucleic acids
Online-Zugang:	https://www.mdpi.com/2218-273X/13/11/1660
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