Endothelial dysfunction and hemostatic imbalance in CAR T-cell-associated toxicities: pathophysiological insights and the role of circulating biomarkers

Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment of relapsed or refractory hematologic malignancies. While its clinical efficacy is well established, CAR T-cell therapy is frequently associated with severe immune-mediated toxicities, including cytokine release syndrome...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Ana Belén Moreno-Castaño, Gontzal Iraola, Núria Martínez-Cibrián, Nil Albiol, Daniel-Nicolás Marco Prats, Julia Martinez-Sanchez, Pedro Castro, Maribel Diaz-Ricart
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-11-01
coleção:	Frontiers in Immunology
Assuntos:	biomarkers biomarker panels CAR T toxicities coagulopathy CRS ICANS
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1699894/full
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!