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Perforin-2 is dispensable for host defense against Aspergillus fumigatus and Candida albicans

ABSTRACT Myeloid phagocytes are essential for antifungal immunity against pulmonary Aspergillus fumigatus and systemic Candida albicans infections. However, the molecular mechanisms underlying fungal clearance by phagocytes remain incompletely understood. In this study, we investigated the role of P...

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Principais autores: Mariano A. Aufiero, Li-Yin Hung, De'Broski R. Herbert, Tobias M. Hohl
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2025-01-01
Serier:mSphere
Fag:
Aspergillus fumigatus
innate immunity
Candida albicans
Perforin
neutrophil
fungi
Online adgang:https://journals.asm.org/doi/10.1128/msphere.00803-24
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