Targeting MYC in combination with epigenetic regulators induces synergistic anti-leukemic effects in MLLr leukemia and simultaneously improves immunity

MLL rearranged (MLLr) leukemias are associated with a poor prognosis and a limited response to conventional therapies. Moreover, chemotherapies result in severe side effects with significant impairment of the immune system. Therefore, the identification of novel treatment strategies is mandatory.Rec...

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Bibliografiska uppgifter

Huvudupphov:	Rahel Fitzel, Kathy-Ann Secker-Grob, Hildegard Keppeler, Fulya Korkmaz, Rebekka Schairer, Estelle Erkner, Dominik Schneidawind, Claudia Lengerke, Thomas Hentrich, Julia M. Schulze-Hentrich, Corina Schneidawind
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Elsevier 2023-07-01
Serie:	Neoplasia: An International Journal for Oncology Research
Ämnen:	MLL-rearranged leukemia MYC MAT2A CRISPR/Cas9 Immune defense
Länkar:	http://www.sciencedirect.com/science/article/pii/S1476558623000271
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