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Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells

Summary: Induction of protective vaccine responses, governed by the successful generation of antigen-specific antibodies and long-lived memory T cells, is increasingly impaired with age. Regulation of the T cell proteome by a dynamic network of microRNAs is crucial to T cell responses. Here, we show...

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Autors principals: Chulwoo Kim, Bin Hu, Rohit R. Jadhav, Jun Jin, Huimin Zhang, Mary M. Cavanagh, Rama S. Akondy, Rafi Ahmed, Cornelia M. Weyand, Jörg J. Goronzy
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2018-11-01
Col·lecció:Cell Reports
Accés en línia:http://www.sciencedirect.com/science/article/pii/S2211124718316784
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