Heat Shock Protein 90 as a Prognostic Marker and Therapeutic Target for Adrenocortical Carcinoma

Background: Adrenocortical carcinoma (ACC) is a rare tumor entity with restricted therapeutic opportunities. HSP90 (Heat Shock Protein 90) chaperone activity is fundamental for cell survival and contributes to different oncogenic signaling pathways. Indeed, agents targeting HSP90 function have shown...

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Auteurs principaux:	Claudia Siebert, Denis Ciato, Masanori Murakami, Ludwig Frei-Stuber, Luis Gustavo Perez-Rivas, José Luis Monteserin-Garcia, Svenja Nölting, Julian Maurer, Annette Feuchtinger, Axel K. Walch, Harm R. Haak, Jérôme Bertherat, Massimo Mannelli, Martin Fassnacht, Esther Korpershoek, Martin Reincke, Günter K. Stalla, Constanze Hantel, Felix Beuschlein
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2019-07-01
Collection:	Frontiers in Endocrinology
Sujets:	adrenal gland cortisol N-terminal HSP90 inhibitors C-terminal HSP90 inhibitors prognostic marker
Accès en ligne:	https://www.frontiersin.org/article/10.3389/fendo.2019.00487/full
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