Positron emission tomography studies of organophosphate chemical threats and oxime countermeasures

There is a unique in vivo interplay involving the mechanism of inactivation of acetylcholinesterase (AChE) by toxic organophosphorus (OP) compounds and the restoration of AChE activity by oxime antidotes. OP compounds form covalent adducts to this critical enzyme target and oximes are introduced to...

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Autors principals:	Charles M. Thompson, John M. Gerdes, Henry F. VanBrocklin
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2020-01-01
Col·lecció:	Neurobiology of Disease
Matèries:	Positron emission tomography (PET) Imaging Biodistribution Pharmacokinetics/toxicokinetics Pharmacodynamics/toxicodynamics Organophosphate/organophosphorus
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S0969996119301007
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