Transient expression of secretory IgA in planta is optimal using a multi-gene vector and may be further enhanced by improving joining chain incorporation

Secretory IgA (sIgA) is a crucial antibody in host defence at mucosal surfaces. It is a promising antibody isotype in a variety of therapeutic settings such as passive vaccination and treatment of inflammatory disorders. However, heterologous production of this heteromultimeric protein complex is st...

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Hlavní autoři:	Lotte eWesterhof, Ruud eWilbers, Debbie evan Raaij, Christina evan Wijk, Aska eGoverse, Jaap eBakker, Arjen eSchots
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2016-01-01
Edice:	Frontiers in Plant Science
Témata:	N-glycosylation Secretory IgA protein complex assembly Ustekinumab Plant-based expression Heteromultimeric
On-line přístup:	http://journal.frontiersin.org/Journal/10.3389/fpls.2015.01200/full
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