An electrostatically conjugated-functional MNK1 aptamer reverts the intrinsic antitumor effect of polyethyleneimine-coated iron oxide nanoparticles in vivo in a human triple-negative cancer xenograft

Abstract Background Triple-negative breast cancer (TNBC) remains a difficult breast cancer subtype to treat as it exhibits a particularly aggressive behavior. The dysregulation of distinct signaling pathways underlies this aggressive behavior, with an overactivation of MAP kinase interacting kinases...

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Hauptverfasser:	Vladimir Mulens-Arias, Yadileiny Portilla, Sonia Pérez-Yagüe, Raquel Ferreras-Martín, M. Elena Martín, Victor M. González, Domingo F. Barber
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2023-06-01
Schriftenreihe:	Cancer Nanotechnology
Schlagworte:	Aptamer MNK1 Polyethyleneimine-coated iron oxide nanoparticles Antitumor effect
Online-Zugang:	https://doi.org/10.1186/s12645-023-00204-8
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