Filling in the gaps in PARP inhibitor-induced synthetic lethality
Tumors with loss of breast cancer type 1 susceptibility protein (BRCA1) are homologous recombination (HR) deficient and hypersensitive to poly(ADP-ribose) polymerase inhibitors (PARPi). However, these tumors may restore HR and acquire PARPi resistance via loss of end-protection of DNA double-strand...
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| Principais autores: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Taylor & Francis Group
2021-11-01
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| Serier: | Molecular & Cellular Oncology |
| Fag: | |
| Online adgang: | http://dx.doi.org/10.1080/23723556.2021.2010512 |
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