Melatonin enhances everolimus efficacy in breast cancer by suppressing mTOR pathway activation and promoting apoptosis and mitochondrial function

Abstract Background Everolimus is used in the treatment of breast cancer by targeting the PI3K/AKT/mTOR pathway, particularly during anti-hormonal therapy. The efficacy of everolimus is limited due to a feedback loop that supresses mTOR while simultaneously enhancing Akt activation in endocrine-resi...

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Autors principals:	Şeyma Demirkesen, Yakup İriağaç, Erdoğan Selçuk Şeber, Cenk Aral
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2025-05-01
Col·lecció:	BMC Pharmacology and Toxicology
Matèries:	Melatonin Everolimus mTOR Apoptosis Autophagy Mitochondrial respiration
Accés en línia:	https://doi.org/10.1186/s40360-025-00907-1
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