Sex-specific differences in abscopal responses to combined radiotherapy and immune checkpoint inhibition–insights from a multicenter study

PurposeAbscopal effects (AbE) during combined radiotherapy (RT) and immune checkpoint inhibition (ICI) represent a potential mechanism for systemic tumor control, yet sex-specific differences in these responses remain largely unexplored. We investigated sex-associated signals in outcomes of combined...

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Egile Nagusiak:	Maike Trommer, Alexander Rühle, Felix Ehret, Allison Lamrani, Charlotte Schmitter, Justus Kaufmann, Matthias Mäurer, Georg Wurschi, Ping Jiang, Andrea Baehr, Annika Hardt, Raphael Bodensohn, Lukas Käsmann, Maria Waltenberger, Eleni Gkika, Davide Scafa, Julian P. Layer, Esther G.C. Troost, Sally A. Elkhamisy, Danny Jazmati, Ilinca Popp, Sebastian Neppl, Anna Hagemeier, Angela Besserer, Simone Ferdinandus
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Frontiers Media S.A. 2026-02-01
Saila:	Frontiers in Immunology
Gaiak:	abscopal effects sex-specific immune effects sex-specific radiation oncology radioimmunotherapy immune checkpoint inhibition
Sarrera elektronikoa:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1699362/full
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