Dynamics of the β-cardiac myosin auto-inhibited state explain cardiomyopathy pathogenesis

Abstract Cardiac contractility requires precise regulation. A recently discovered form of regulation of cardiac contractility involves a β-cardiac myosin off-state, the Interacting-Heads Motif (CarIHM). Despite its central role in cardiac physiology and disease, CarIHM structural dynamics remain poo...

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Библиографические подробности

Главные авторы:	Daniel Auguin, Laurie Lannes, Carlos Kikuti, Nour Ayoub, Marie Juillé, Stéphane Réty, Neha Nandwani, Divya Pathak, Kathleen M. Ruppel, James A. Spudich, Julien Robert-Paganin, Anne Houdusse
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Nature Portfolio 2026-06-01
Серии:	Nature Communications
Online-ссылка:	https://doi.org/10.1038/s41467-026-73572-5
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